* In the television series The Simpsons, Apu and Manjula Nahasapeemapetilon had octuplets: Anoop, Uma, Nabendu, Poonam, Pria, Sandeep, Sashi, and Gheet (also known as Lincoln, Freedom, Condoleezza, Coke, Pepsi, Manifest Destiny, Apple Pie, and Superman). They were a result of an overdosage of fertility drugs.
o The record was soon broken by a couple with nonuplets in Shelbyville, the archenemy of Springfield.
* In the television series Quintuplets, there are five children born simultaneously: Parker, Pierce, Patton, Penny, and Paige.
* In the movie Raising Arizona, the plot is largely driven by the protagonists' kidnapping of Nathan Arizona, Jr., one of a set of quintuplets.
* A series story published on-line features the identical Carlson Septuplets.
* Among Disney characters, multiple births seem to be rather common. Donald Duck's nephews, Huey, Dewey and Louie are triplets; and so are Daisy Duck's nieces, April, May and June. Mickey Mouse's nephews, Morty and Ferdie Fieldmouse, are twins, as are Tweedledee and Tweedledum from Disney's Alice in Wonderland based on the Lewis Carroll stories. Even the Beagle Boys have a set of triplet descendants, the Beagle Brats.
* In Friends, Phoebe Buffay gave birth to her brother's triplets.